新质生产力在湖北 | 宜昌人福药业：从“仿”到“创”的突围路
<p style="box-sizing: border-box; -webkit-tap-highlight-color: transparent; margin-top: 1.5em; margin-bottom: 1.5em; padding: 0px; word-break: break-word; text-align: justify; text-indent: 2em; font-size: 18px; line-height: 1.8; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, Helvetica, Segoe UI, Arial, Roboto, PingFang SC, miui, Hiragino Sans GB, Microsoft Yahei, sans-serif; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);">做创新药，投入大、周期长、风险高；做仿制药，能快速上市，核心技术却受制于人。如何破局突围？作为全国最大的麻醉药品定点研发生产企业，宜昌人福药业正以人才为核、AI赋能，加速从仿制药到创新药的转型，为百姓提供更多放心好药。<br style="box-sizing: border-box; -webkit-tap-highlight-color: transparent;"/></p><p style="box-sizing: border-box; -webkit-tap-highlight-color: transparent; margin-top: 1.5em; margin-bottom: 1.5em; padding: 0px; word-break: break-word; text-align: justify; text-indent: 2em; font-size: 18px; line-height: 1.8; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, Helvetica, Segoe UI, Arial, Roboto, PingFang SC, miui, Hiragino Sans GB, Microsoft Yahei, sans-serif; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);">近日，宜昌人福药业研发的2.2类新药——氨酚羟考酮缓释片上市许可申请获得受理，这是国内首个申报上市的该剂型药品。像这样的创新药，企业每年都有十多款推向市场，而在六年前，他们的主营产品还以仿制药为主。</p><p style="box-sizing: border-box; -webkit-tap-highlight-color: transparent; margin-top: 1.5em; margin-bottom: 1.5em; padding: 0px; word-break: break-word; text-align: justify; text-indent: 2em; font-size: 18px; line-height: 1.8; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, Helvetica, Segoe UI, Arial, Roboto, PingFang SC, miui, Hiragino Sans GB, Microsoft Yahei, sans-serif; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);"><strong style="box-sizing: border-box; -webkit-tap-highlight-color: transparent;">宜昌人福药业有限责任公司副总经理 田峦鸢：</strong>仿制药就是已上市的药品，然后国内从原料、辅料一模一样地仿制。这种仿制的生产厂家会有很多家，利润基本上微乎其微。创新药针对的是未被满足的临床需求，那么它在市场价值的认可上会有很大的提升。</p><p style="box-sizing: border-box; -webkit-tap-highlight-color: transparent; margin-top: 1.5em; margin-bottom: 1.5em; padding: 0px; word-break: break-word; text-align: justify; text-indent: 2em; font-size: 18px; line-height: 1.8; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, Helvetica, Segoe UI, Arial, Roboto, PingFang SC, miui, Hiragino Sans GB, Microsoft Yahei, sans-serif; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);">转型并非一蹴而就。宜昌人福药业主攻麻醉镇痛镇静药品领域，研发团队在长期临床调研中发现，传统镇静药物普遍存在呼吸抑制、苏醒时间长等副作用。瞄准这一临床痛点，企业在2010年启动苯磺酸瑞马唑仑创新药研发，历经十年攻关，2020年，这款全省首个化药1类新药成功上市，打破了国内外临床广泛使用的镇静药物领域近30年无创新药上市的局面。</p><p style="box-sizing: border-box; -webkit-tap-highlight-color: transparent; margin-top: 1.5em; margin-bottom: 1.5em; padding: 0px; word-break: break-word; text-align: justify; text-indent: 2em; font-size: 18px; line-height: 1.8; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, Helvetica, Segoe UI, Arial, Roboto, PingFang SC, miui, Hiragino Sans GB, Microsoft Yahei, sans-serif; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);"><strong style="box-sizing: border-box; -webkit-tap-highlight-color: transparent;">宜昌人福药业有限责任公司副总经理 田峦鸢：</strong>从无到有的这个过程，积累了很好的做创新药的经验，也是充分认识到最缺的还是人才。</p><p style="box-sizing: border-box; -webkit-tap-highlight-color: transparent; margin-top: 1.5em; margin-bottom: 1.5em; padding: 0px; word-break: break-word; text-align: justify; text-indent: 2em; font-size: 18px; line-height: 1.8; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, Helvetica, Segoe UI, Arial, Roboto, PingFang SC, miui, Hiragino Sans GB, Microsoft Yahei, sans-serif; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);">锚定创新方向，宜昌人福药业果断调整研发布局，拿出销售额的10%到12%投入研发。去年，企业集中资源加码创新药攻坚，携手英国、德国等国家的高校和企业共建研发机构，广纳海内外高端英才。清华大学博士盛锡军就作为高端人才加盟企业，牵头组建了一支覆盖药物化学、生物药理学、AI计算等多个前沿领域的创新研发团队。</p><p style="box-sizing: border-box; -webkit-tap-highlight-color: transparent; margin-top: 1.5em; margin-bottom: 1.5em; padding: 0px; word-break: break-word; text-align: justify; text-indent: 2em; font-size: 18px; line-height: 1.8; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, Helvetica, Segoe UI, Arial, Roboto, PingFang SC, miui, Hiragino Sans GB, Microsoft Yahei, sans-serif; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);"><strong style="box-sizing: border-box; -webkit-tap-highlight-color: transparent;">宜昌人福药业有限责任公司创新研究中心主任 盛锡军：</strong>过去的三年当中，我们总共引进了32位博士，AI加药物研发的复合型人才的引进极大助力了我们新药的研发。</p><p style="box-sizing: border-box; -webkit-tap-highlight-color: transparent; margin-top: 1.5em; margin-bottom: 1.5em; padding: 0px; word-break: break-word; text-align: justify; text-indent: 2em; font-size: 18px; line-height: 1.8; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, Helvetica, Segoe UI, Arial, Roboto, PingFang SC, miui, Hiragino Sans GB, Microsoft Yahei, sans-serif; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);">人才与资源的汇聚，正在转化为实实在在的研发效率。去年，企业自主研发的AI化合物分析与筛选平台“MolStata”正式上线，将药物立项到发现临床候选化合物的研发时间由18个月缩短至12个月，目前该平台已在20多个创新药项目中投入使用。</p><p style="box-sizing: border-box; -webkit-tap-highlight-color: transparent; margin-top: 1.5em; margin-bottom: 1.5em; padding: 0px; word-break: break-word; text-align: justify; text-indent: 2em; font-size: 18px; line-height: 1.8; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, Helvetica, Segoe UI, Arial, Roboto, PingFang SC, miui, Hiragino Sans GB, Microsoft Yahei, sans-serif; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);"><strong style="box-sizing: border-box; -webkit-tap-highlight-color: transparent;">宜昌人福药业有限责任公司创新研究中心主任 盛锡军：</strong>一把钥匙开一把锁，锁比作药物作用的一个靶点，钥匙就比作一款药物分子，只有匹配的时候才能开锁。通过AI的方法来预测，就为我们提供了一个很好的参考。</p><p style="box-sizing: border-box; -webkit-tap-highlight-color: transparent; margin-top: 1.5em; margin-bottom: 1.5em; padding: 0px; word-break: break-word; text-align: justify; text-indent: 2em; font-size: 18px; line-height: 1.8; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, Helvetica, Segoe UI, Arial, Roboto, PingFang SC, miui, Hiragino Sans GB, Microsoft Yahei, sans-serif; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);">2025年以来，宜昌人福药业2款1类新药获批临床试验，创新研发跑出加速度。如今，企业的创新布局也从麻醉镇痛领域，延伸至肿瘤疼痛、精神神经等多个赛道，同时，打造出“上市一批、临床一批、研究一批”的梯次科研项目梯队，持续培育发展新动能。</p><section style="font-size: 17px; letter-spacing: 1px; line-height: 2; box-sizing: border-box; text-align: justify; color: rgb(62, 62, 62);"><section style="box-sizing: border-box;"><p style="text-wrap-mode: wrap; margin-top: 0px; margin-bottom: 0px; padding: 0px; box-sizing: border-box;"><br style="box-sizing: border-box;"/></p><section style="max-width: 100%; color: rgb(67, 74, 84); font-family: -apple-system-font, Helvetica, PingFang SC, Hiragino Sans GB, Arial, Microsoft YaHei; text-wrap-mode: wrap; background-color: rgb(255, 255, 255); margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; box-sizing: border-box; overflow-wrap: break-word !important;"><section style="max-width: 100%; margin: 0.5em 0px; padding: 0px; outline: 0px; overflow-wrap: break-word !important; box-sizing: border-box;"><section style="max-width: 100%; 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